SR-2959

Modify Date: 2024-01-09 17:55:21

SR-2959 Structure
SR-2959 structure
Common Name SR-2959
CAS Number 1632125-79-1 Molecular Weight 479.54
Density 1.5±0.1 g/cm3 Boiling Point 711.7±70.0 °C at 760 mmHg
Molecular Formula C21H22FN3O5S2 Melting Point N/A
MSDS N/A Flash Point 384.2±35.7 °C

 Use of SR-2959


ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC50 value of 188 nM. ML345 can be for use as a pharmacophore for drug development in diabetes research[1].

 Names

Name 5-Fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one
Synonym More Synonyms

 SR-2959 Biological Activity

Description ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC50 value of 188 nM. ML345 can be for use as a pharmacophore for drug development in diabetes research[1].
Related Catalog
Target

IC50: 188 nM (IDE)[1]

References

[1]. Bannister TD, et al. ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE). In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); December 17, 2012.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 711.7±70.0 °C at 760 mmHg
Molecular Formula C21H22FN3O5S2
Molecular Weight 479.54
Flash Point 384.2±35.7 °C
Exact Mass 479.098480
LogP 1.32
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.658

 Synonyms

1,2-Benzisothiazol-3(2H)-one, 5-fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-
5-Fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one