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SR-2959

Names

[ CAS No. ]:
1632125-79-1

[ Name ]:
SR-2959

[Synonym ]:
1,2-Benzisothiazol-3(2H)-one, 5-fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-
5-Fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-1,2-benzothiazol-3(2H)-one

Biological Activity

[Description]:

ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC50 value of 188 nM. ML345 can be for use as a pharmacophore for drug development in diabetes research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: 188 nM (IDE)[1]


[References]

[1]. Bannister TD, et al. ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE). In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); December 17, 2012.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
711.7±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H22FN3O5S2

[ Molecular Weight ]:
479.54

[ Flash Point ]:
384.2±35.7 °C

[ Exact Mass ]:
479.098480

[ LogP ]:
1.32

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.658

Related Compounds