GNE-131
Modify Date: 2024-03-03 13:07:16
GNE-131 structure
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Common Name | GNE-131 | ||
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| CAS Number | 1629063-81-5 | Molecular Weight | 442.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H30N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE-131GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. |
| Name | GNE-131 |
|---|
| Description | GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. |
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| Related Catalog | |
| Target |
IC50: 3 nM (hNaV1.7)[1]. |
| In Vitro | GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability[1]. |
| In Vivo | GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain[1]. |
| References |
| Molecular Formula | C23H30N4O3S |
|---|---|
| Molecular Weight | 442.57 |
| Storage condition | 2-8℃ |