GNE-131

Modify Date: 2024-03-03 13:07:16

GNE-131 structure	Common Name	GNE-131
	CAS Number	1629063-81-5	Molecular Weight	442.57
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₀N₄O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GNE-131

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.

Name	GNE-131

Description	GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	IC50: 3 nM (hNaV1.7)[1].
In Vitro	GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability[1].
In Vivo	GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain[1].
References	[1]. Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14;61(11):4810-4831.

Molecular Formula	C₂₃H₃₀N₄O₃S
Molecular Weight	442.57
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: GNE-131
Price: $500.0/5mg $750.0/10mg $980.0/25mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥4950/10 mM * 1 mL in DMSO

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