1496581-76-0

1496581-76-0 structure

Name: GNE-3511
Chemical Name: 2-({6-(3,3-Difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl}amino)isonicotinonitrile
CAS Number: 1496581-76-0
Molecular Formula: C₂₃H₂₆F₂N₆O
Molecular Weight: 440.489
Catalog: Signaling Pathways MAPK/ERK Pathway MAP3K
Create Date: 2018-05-20 09:41:40
Modify Date: 2025-08-26 15:19:10
GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM.

Name	2-({6-(3,3-Difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl}amino)isonicotinonitrile
Synonyms	4-Pyridinecarbonitrile, 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]- 2-({6-(3,3-Difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl}amino)isonicotinonitrile GNE-3511

Description	GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP3K Research Areas >> Cancer
References	[1]. Patel S et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem. 2015 Jan 8;58(1):401-18.