ARN-3236

Modify Date: 2024-01-11 15:52:23

ARN-3236 structure	Common Name	ARN-3236
	CAS Number	1613710-01-2	Molecular Weight	336.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₆N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ARN-3236

ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2) (IC50 <1 nM), with activity in inhibiting growth and enhancing paclitaxel sensitivity in cultures and xenografts of ovarian cancer cell lines[1][2].

Name	ARN-3236
Synonym	More Synonyms

Description	ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2) (IC50 <1 nM), with activity in inhibiting growth and enhancing paclitaxel sensitivity in cultures and xenografts of ovarian cancer cell lines[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)
Target	SIK2:<1 nM (IC50) SIK1:21.63 nM (IC50) SIK3:6.63 nM (IC50)
References	[1]. Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99(5):711-21. [2]. Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954.

Molecular Formula	C₁₉H₁₆N₂O₂S
Molecular Weight	336.41
Storage condition	2-8℃

3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE

DC Chemicals Limited
China
Product Name: ARN-3236
Price: $550.0/100mg $950.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥2220/10 mM * 1 mL in DMSO

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ARN-3236

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