Name | ARN-5187 |
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Description | A novel lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy; relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells; disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability; a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine. |
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References | References 1. De Mei C, et al. Oncogene. 2015 May 14;34(20):2597-608. View Related Products by Target Autophagy |
Molecular Formula | C24H32FN3O |
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Molecular Weight | 397.538 |