ARN-5187
Modify Date: 2025-09-10 22:59:52
ARN-5187 structure
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Common Name | ARN-5187 | ||
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| CAS Number | 1287451-26-6 | Molecular Weight | 397.538 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H32FN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ARN-5187A novel lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy; relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells; disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability; a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine. |
| Name | ARN-5187 |
|---|
| Description | A novel lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy; relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells; disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability; a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine. |
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| References | References 1. De Mei C, et al. Oncogene. 2015 May 14;34(20):2597-608. View Related Products by Target Autophagy |
| Molecular Formula | C24H32FN3O |
|---|---|
| Molecular Weight | 397.538 |
| InChIKey | RMYLFPZPIDTXQK-UHFFFAOYSA-N |
| SMILES | CN1CCN(Cc2cc(CNC3(c4ccccc4F)CCCC3)ccc2O)CC1 |