1373625-34-3

1373625-34-3 structure

Name: ARN 077
Chemical Name: ARN 077
CAS Number: 1373625-34-3
Molecular Formula: C₁₆H₂₁NO₄
Molecular Weight: 291.34
Catalog: Research Areas Inflammation/Immunology
Create Date: 2019-03-30 20:02:34
Modify Date: 2024-01-28 10:12:51
ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA[1]. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats[2].

Name	ARN 077

Description	ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA[1]. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 7 nM (human NAAA)[1].
References	[1]. Sasso O, et al. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar;154(3):350-60. [2]. Davis MP, et al. Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. Expert Opin Investig Drugs. 2014 Aug;23(8):1123-40.

Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34