2436472-46-5
2436472-46-5 structure
- Name: ARN-75041
- Chemical Name: ARN-75041
- CAS Number: 2436472-46-5
- Molecular Formula: C27H30N2O2
- Molecular Weight: 414.549
- Create Date: 2022-08-14 11:14:34
- Modify Date: 2024-01-03 14:53:42
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ARN-75041 (ARN75041) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 1.7 and 15.3 nM, respectively. ARN-75041 demonstrated sub-nanomolar against native replicative LASV (LASV EC90<0.3 nM) and JUNV (EC90=6.2 nM).ARN-75041 also potently inhibits mutant T434I pTCRV variant with EC50 of 29 nM.ARN-75041 dramatically improved survival outcome and potently inhibited TCRV replication in serum and various tissues at doses of 10 and 35 mg/kg, provided highly significant post-exposure protection in mice against TCRV infection.
| Name | ARN-75041 |
|---|
| Description | ARN-75041 (ARN75041) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 1.7 and 15.3 nM, respectively. ARN-75041 demonstrated sub-nanomolar against native replicative LASV (LASV EC90<0.3 nM) and JUNV (EC90=6.2 nM).ARN-75041 also potently inhibits mutant T434I pTCRV variant with EC50 of 29 nM.ARN-75041 dramatically improved survival outcome and potently inhibited TCRV replication in serum and various tissues at doses of 10 and 35 mg/kg, provided highly significant post-exposure protection in mice against TCRV infection. |
|---|---|
| References | 1. Brian B Gowen, et al. Antiviral Res. 2021 Sep;193:105125. 2. Michael B Plewe, et al. Bioorg Med Chem Lett. 2021 Jun 1;41:127983. |
| Molecular Formula | C27H30N2O2 |
|---|---|
| Molecular Weight | 414.549 |