Adrenomedullin (22-52) (human)

Modify Date: 2025-08-21 17:03:41

Adrenomedullin (22-52) (human) structure	Common Name	Adrenomedullin (22-52) (human)
	CAS Number	159899-65-7	Molecular Weight	3576.03
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅₉H₂₅₂N₄₆O₄₈	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Adrenomedullin (22-52) (human)

Adrenomedullin (AM) (22-52), human is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

Name	Adrenomedullin(22-52)(Human)
Synonym	More Synonyms

Description	Adrenomedullin (AM) (22-52), human is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Peptides Research Areas >> Cardiovascular Disease
Target	Adrenomedullin receptor, CGRP receptor[1]
In Vitro	Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist[1].
References	[1]. Champion HC, et al. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997 Jan;272(1 Pt 2):R234-42.

Molecular Formula	C₁₅₉H₂₅₂N₄₆O₄₈
Molecular Weight	3576.03
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Adrenomedullin receptor binding sites in rat brain and peripheral tissues.

Eur. J. Pharmacol. 474 , 165-174, (2003)

The existence of specific adrenomedullin receptor binding sites was investigated using the agonist peptide fragment [125I]human adrenomedullin-(13-52) in rat brain, lung and vas deferens homogenates. ...

Adrenomedullin is anti-apoptotic in osteoblasts through CGRP1 receptors and MEK-ERK pathway.

J. Cell Physiol. 215 , 122-128, (2008)

Adrenomedullin (ADM) has been shown to mediate multifunctional responses in cell culture and animal system such as regulation of growth and apoptosis. ADM stimulates the proliferation of osteoblasts i...

Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis.

Oncogene 22 , 1238-1242, (2003)

Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreat...

MFCD00282038

Adrenomedullin (AM) (22-52), human