C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acetate salt

Modify Date: 2024-01-02 19:45:13

C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acetate salt Structure
C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acetate salt structure
Common Name C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acetate salt
CAS Number 127869-51-6 Molecular Weight 2197.60000
Density N/A Boiling Point N/A
Molecular Formula C93H157N27O28S3 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acetate salt


C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide. C-type natriuretic peptide is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone.

 Names

Name Natriuretic peptide, C-type
Synonym More Synonyms

  Biological Activity

Description C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide. C-type natriuretic peptide is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone.
Related Catalog
In Vitro C-Type Natriuretic Peptide (CNP) has been shown to be present in the central nervous system of mammals and to participate in the regulation of the homeostasis of the fluid, electrolytic balance and blood pressure, learning and memory[1].
In Vivo I.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide[1].
Animal Admin Rats[1] Rats are preliminarily kindled with picrotoxin and convulsion is monitored. Rats then receive I.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) (0.2, 1 or 2 nM in 2 mcl of 0.9% NaCI) under conditions of free behavior. Control animals receive an equal volume of saline. Within 10 min after the injections of the peptides, picrotoxin (1.5 mg/kg) is administered i.p. and the convulsion severity is evaluated as mentioned above[1].
References

[1]. Mazarati AM, et al. ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats. Life Sci. 1993;52(3):PL19-24.

 Chemical & Physical Properties

Molecular Formula C93H157N27O28S3
Molecular Weight 2197.60000
Exact Mass 2196.09000
PSA 962.25000
LogP 0.46880
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3.0

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 Synonyms

Dihydrexidine hydrochloride
MFCD00080348
C-Type natriuretic peptide
GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS(DISULFIDE BRIDGE:CYS6-CYS22)
NATRIURETIC PEPTIDE,C-TYPE
CNP
GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS: GLSKGCFGLKLDRIGSMSGLGCDISULFIDE BRIDGE CYS6-CYS22
C-Type Natriuretic Peptide (CNP) (1-22), human
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