Propargyl-PEG5-amine
Modify Date: 2024-01-10 13:50:11
Propargyl-PEG5-amine structure
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Common Name | Propargyl-PEG5-amine | ||
|---|---|---|---|---|
| CAS Number | 1589522-46-2 | Molecular Weight | 275.341 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 360.4±37.0 °C at 760 mmHg | |
| Molecular Formula | C13H25NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 166.5±20.2 °C | |
Use of Propargyl-PEG5-aminePropargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
| Name | Propargyl-PEG5-amine |
|---|---|
| Synonym | More Synonyms |
| Description | Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1. |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 360.4±37.0 °C at 760 mmHg |
| Molecular Formula | C13H25NO5 |
| Molecular Weight | 275.341 |
| Flash Point | 166.5±20.2 °C |
| Exact Mass | 275.173279 |
| LogP | -1.54 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.464 |
| PROPARGYL-PEG5-NH2 |