2098489-63-3

2098489-63-3 structure

Name: Propargyl-PEG5-CH2CO2tBu
Chemical Name: Propargyl-PEG4-O-C1-Boc
CAS Number: 2098489-63-3
Molecular Formula: C₁₇H₃₀O₇
Molecular Weight: 346.42
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-04-07 18:07:33
Modify Date: 2024-01-10 19:44:11
Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	Propargyl-PEG4-O-C1-Boc

Description	Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.