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Propargyl-PEG5-amine

Names

[ CAS No. ]:
1589522-46-2

[ Name ]:
Propargyl-PEG5-amine

[Synonym ]:
PROPARGYL-PEG5-NH2

Biological Activity

[Description]:

Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
360.4±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H25NO5

[ Molecular Weight ]:
275.341

[ Flash Point ]:
166.5±20.2 °C

[ Exact Mass ]:
275.173279

[ LogP ]:
-1.54

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.464

Related Compounds