Gallocyanine

Modify Date: 2024-01-03 19:11:43

Gallocyanine Structure
Gallocyanine structure
Common Name Gallocyanine
CAS Number 1562-85-2 Molecular Weight 336.727
Density 1.3979 (rough estimate) Boiling Point 497ºC at 760 mmHg
Molecular Formula C15H13ClN2O5 Melting Point N/A
MSDS Chinese USA Flash Point 254.4ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Gallocyanine


Gallocyanine chloride, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Its association with LRP6 is weak (IC50 of about 3 μM in the inhibition of DKK1 binding). Gallocyanine dye acts as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies[1].

 Names

Name Gallocyanine
Synonym More Synonyms

 Gallocyanine Biological Activity

Description Gallocyanine chloride, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Its association with LRP6 is weak (IC50 of about 3 μM in the inhibition of DKK1 binding). Gallocyanine dye acts as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies[1].
Related Catalog
References

[1]. Spyros Mpousis, et al. Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies. Eur J Med Chem. 2016 Jan 27;108:28-38.

 Chemical & Physical Properties

Density 1.3979 (rough estimate)
Boiling Point 497ºC at 760 mmHg
Molecular Formula C15H13ClN2O5
Molecular Weight 336.727
Flash Point 254.4ºC
Exact Mass 336.051300
PSA 107.03000
Index of Refraction 1.6500 (estimate)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SP7692000
CHEMICAL NAME :
Phenoxazin-5-ium, 1-carboxy-7-(dimethylamino)-3,4-dihydroxy-, chloride
CAS REGISTRY NUMBER :
1562-85-2
LAST UPDATED :
199504
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H13-N2-O5.Cl
MOLECULAR WEIGHT :
336.75
WISWESSER LINE NOTATION :
T C666 BN IOJ DVQ FQ GQ LN1&1 &G &12/32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
1000 ppm
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year: 87,295,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3052 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 131 (estimated) No. of Female Employees: 81 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S36/37
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS SP7692000
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles24

More Articles
[Determination of the relative RNA-content of liver cell nuclei with gallocyanin-chromealum-staining (author's transl)].

Acta Histochem. 69(2) , 307-13, (1981)

The relative RNA-content of liver cell nuclei from histological slides of rat liver was determined by automatical microscope picture analysis. The slides were stained with Gallocyanin-Chromealum. Exti...

Remarks on the usefulness of toluidine blue staining for RNA cytophotometry in plastic embedded tissues.

Cell Mol. Biol. 45(4) , 379-82, (1999)

The study demonstrates the usefulness of water-soluble plastic resins for the cytological quantification of RNA contents after toluidine blue staining. In this way shrinkage artefacts in delicate tiss...

The involvement of nucleosomes in Giemsa staining of chromosomes. A new hypothesis on the banding mechanism.

Histochemistry 82(4) , 363-76, (1985)

A new hypothesis is proposed on the involvement of nucleosomes in Giemsa banding of chromosomes. Giemsa staining as well as the concomitant swelling can be explained as an insertion of the triple char...

 Synonyms

EINECS 216-345-7
C.I. Mordant Blue 10 (8CI)
MFCD00011926
1-Carboxy-7-(dimethylamino)-3,4-dihydroxyphenoxazin-5-ium chloride
7-Dimethylamino-4-hydroxy-3-oxo-phenoxazine-1-carboxylic acid
Phenoxazinium, 1-carboxy-7-(dimethylamino)-3,4-dihydroxy-, chloride (1:1)
Gallocyanine
Phenoxazin-5-ium, 1-carboxy-7- (dimethylamino)-3,4-dihydroxy-, chloride
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