Pomalidomide-6-OH
Modify Date: 2024-02-05 19:16:30
Pomalidomide-6-OH structure
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Common Name | Pomalidomide-6-OH | ||
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| CAS Number | 1547162-44-6 | Molecular Weight | 289.24 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 674.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C13H11N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 361.8±31.5 °C | |
Use of Pomalidomide-6-OHPomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC[1]. |
| Name | 4-Amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-1H-isoindole-1,3(2H)-dione |
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| Synonym | More Synonyms |
| Description | Pomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC[1]. |
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| Related Catalog | |
| Target |
Cereblon |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 674.7±55.0 °C at 760 mmHg |
| Molecular Formula | C13H11N3O5 |
| Molecular Weight | 289.24 |
| Flash Point | 361.8±31.5 °C |
| Exact Mass | 289.069885 |
| LogP | -1.34 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.725 |
| Storage condition | 2-8°C |
| 4-Amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-1H-isoindole-1,3(2H)-dione |
| 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy- |