1547163-08-5

1547163-08-5 structure

Name: Pomalidomide-6-O-CH3
Chemical Name: Pomalidomide-6-O-CH3
CAS Number: 1547163-08-5
Molecular Formula: C₁₄H₁₃N₃O₅
Molecular Weight: 303.27
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2021-12-20 13:07:01
Modify Date: 2025-08-23 01:04:23
Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].

Name	Pomalidomide-6-O-CH3

Description	Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.