1547162-44-6

1547162-44-6 structure

Name: Pomalidomide-6-OH
Chemical Name: 4-Amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-1H-isoindole-1,3(2H)-dione
CAS Number: 1547162-44-6
Molecular Formula: C₁₃H₁₁N₃O₅
Molecular Weight: 289.24
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2022-01-12 19:02:13
Modify Date: 2025-08-26 11:14:02
Pomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC[1].

Name	4-Amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-1H-isoindole-1,3(2H)-dione
Synonyms	4-Amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-1H-isoindole-1,3(2H)-dione 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-

Description	Pomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.