1547162-41-3
1547162-41-3 structure
- Name: Pomalidomide-5-OH
- Chemical Name: CC-17368
- CAS Number: 1547162-41-3
- Molecular Formula: C13H11N3O5
- Molecular Weight: 289.24
- Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
- Create Date: 2022-01-01 20:08:37
- Modify Date: 2024-01-14 12:26:56
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Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].
| Name | CC-17368 |
|---|---|
| Synonyms |
4-Amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione
CC-17368 MFCD32199595 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- 2JD83JK9RC UNII:2JD83JK9RC |
| Description | Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1]. |
|---|---|
| Related Catalog | |
| Target |
Cereblon |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 633.0±55.0 °C at 760 mmHg |
| Molecular Formula | C13H11N3O5 |
| Molecular Weight | 289.24 |
| Flash Point | 336.6±31.5 °C |
| Exact Mass | 289.069885 |
| LogP | -1.24 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.725 |
| Storage condition | 2-8°C |