Inosine,2-chloro-6-O-methyl- (9CI)

Modify Date: 2025-08-25 22:49:59

Inosine,2-chloro-6-O-methyl- (9CI) Structure
Inosine,2-chloro-6-O-methyl- (9CI) structure
 Common Name Inosine,2-chloro-6-O-methyl- (9CI)
CAS Number 15465-92-6 Molecular Weight 316.70
Density 1.95g/cm3 Boiling Point 587.8ºC at 760mmHg
Molecular Formula C11H13ClN4O5 Melting Point 140 °C(Solv: isopropanol (67-63-0))
MSDS N/A Flash Point 309.3ºC

 Use of Inosine,2-chloro-6-O-methyl- (9CI)


2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

 Names

Name 2-Chloro-6-O-methyl-inosine
Synonym More Synonyms

 Inosine,2-chloro-6-O-methyl- (9CI) Biological Activity

Description 2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
Related Catalog
References

[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.  

[2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.  

 Chemical & Physical Properties

Density 1.95g/cm3
Boiling Point 587.8ºC at 760mmHg
Melting Point 140 °C(Solv: isopropanol (67-63-0))
Molecular Formula C11H13ClN4O5
Molecular Weight 316.70
Flash Point 309.3ºC
Exact Mass 316.05700
PSA 122.75000
Vapour Pressure 1.16E-14mmHg at 25°C
Index of Refraction 1.784

 Synonyms

2-(2-chloro-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
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