Neamine tetrahydrochloride
Modify Date: 2025-08-27 09:54:08
Neamine tetrahydrochloride structure
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Common Name | Neamine tetrahydrochloride | ||
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| CAS Number | 15446-43-2 | Molecular Weight | 468.20200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H30Cl4N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Neamine tetrahydrochlorideNeamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2]. |
| Name | Neamine Hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2]. |
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| Related Catalog | |
| In Vitro | Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1]. Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1]. Cell Proliferation Assay[1] Cell Line: AsPC-1 cells Concentration: 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM Incubation Time: 48 hours Result: Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation. |
| In Vivo | Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1]. Animal Model: Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1] Dosage: 30 mg/kg, 60 mg/kg Administration: Subcutaneous injection; daily; for 14 days Result: Had anti-tumor effects on AsPC-1 xenograft models. |
| References |
| Molecular Formula | C12H30Cl4N4O6 |
|---|---|
| Molecular Weight | 468.20200 |
| Exact Mass | 466.09200 |
| PSA | 203.46000 |
| LogP | 0.89360 |
|
~89%
Neamine tetrahy... CAS#:15446-43-2 |
| Literature: Van Den Broek, Sebastiaan A. M. W.; Gruijters, Bas W. T.; Rutjes, Floris P. J. T.; Van Delft, Floris L.; Blaauw, Richard H. Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3577 - 3580 |
|
~92%
Neamine tetrahy... CAS#:15446-43-2 |
| Literature: Andac, Cenk A.; Stringfellow, Thomas C.; Hornemann, Ulfert; Noyanalpan, Ningur Bioorganic Chemistry, 2011 , vol. 39, # 1 p. 28 - 41 |
| neamine hydrochloride |