DC Chemicals Limited
China
Product Name: Neamine tetrahydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

15446-43-2

15446-43-2 structure

Name: Neamine tetrahydrochloride
Chemical Name: Neamine Hydrochloride
CAS Number: 15446-43-2
Molecular Formula: C₁₂H₃₀Cl₄N₄O₆
Molecular Weight: 468.20200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-06-08 23:22:51
Modify Date: 2024-01-14 16:11:18
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2].

Name	Neamine Hydrochloride
Synonyms	neamine hydrochloride

Description	Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1]. Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1]. Cell Proliferation Assay[1] Cell Line: AsPC-1 cells Concentration: 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM Incubation Time: 48 hours Result: Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.
In Vivo	Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1]. Animal Model: Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1] Dosage: 30 mg/kg, 60 mg/kg Administration: Subcutaneous injection; daily; for 14 days Result: Had anti-tumor effects on AsPC-1 xenograft models.
References	[1]. Ya-Ping Liu, et al. Neamine Inhibits Growth of Pancreatic Cancer Cells in Vitro and in Vivo. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):82-87. [2]. R Ning, et al. Neamine Induces Neuroprotection After Acute Ischemic Stroke in Type One Diabetic Rats. Neuroscience. 2014 Jan 17;257:76-85.

Molecular Formula	C₁₂H₃₀Cl₄N₄O₆
Molecular Weight	468.20200
Exact Mass	466.09200
PSA	203.46000
LogP	0.89360

25389-98-4

~89%

15446-43-2

Literature: Van Den Broek, Sebastiaan A. M. W.; Gruijters, Bas W. T.; Rutjes, Floris P. J. T.; Van Delft, Floris L.; Blaauw, Richard H. Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3577 - 3580

119-04-0

~92%

15446-43-2

Literature: Andac, Cenk A.; Stringfellow, Thomas C.; Hornemann, Ulfert; Noyanalpan, Ningur Bioorganic Chemistry, 2011 , vol. 39, # 1 p. 28 - 41

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