15446-43-2
15446-43-2 structure
- Name: Neamine tetrahydrochloride
- Chemical Name: Neamine Hydrochloride
- CAS Number: 15446-43-2
- Molecular Formula: C12H30Cl4N4O6
- Molecular Weight: 468.20200
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2017-06-08 23:22:51
- Modify Date: 2025-08-27 09:54:08
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Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2].
| Name | Neamine Hydrochloride |
|---|---|
| Synonyms | neamine hydrochloride |
| Description | Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1]. Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1]. Cell Proliferation Assay[1] Cell Line: AsPC-1 cells Concentration: 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM Incubation Time: 48 hours Result: Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation. |
| In Vivo | Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1]. Animal Model: Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1] Dosage: 30 mg/kg, 60 mg/kg Administration: Subcutaneous injection; daily; for 14 days Result: Had anti-tumor effects on AsPC-1 xenograft models. |
| References |
| Molecular Formula | C12H30Cl4N4O6 |
|---|---|
| Molecular Weight | 468.20200 |
| Exact Mass | 466.09200 |
| PSA | 203.46000 |
| LogP | 0.89360 |
