Ginkgolide C

Modify Date: 2024-01-02 10:18:47

Ginkgolide C structure	Common Name	Ginkgolide C
	CAS Number	15291-76-6	Molecular Weight	440.398
	Density	1.7±0.1 g/cm3	Boiling Point	813.8±65.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₄O₁₁	Melting Point	>3000ºC
	MSDS	Chinese USA	Flash Point	291.4±27.8 °C

Use of Ginkgolide C

Ginkgolide C is a flavone isolated from Ginkgo biloba leaves, possessing multiple biological functions, such as decreasing platelet aggregation and ameliorating Alzheimer disease.

Name	Ginkgolide C
Synonym	More Synonyms

Description	Ginkgolide C is a flavone isolated from Ginkgo biloba leaves, possessing multiple biological functions, such as decreasing platelet aggregation and ameliorating Alzheimer disease.
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides
Target	AMPK MMP-9 Sirtuin
In Vitro	Ginkgolide C (3-100 μM) has no significant effect on 3T3-L1 cell viability, but suppresses adipogenesis in 3T3-L1 cells followling 24 h treatment. Ginkgolide C (10-100 μM) significantly suppresses lipid accumulation compared with the control group and also significantly promotes glycerol release in 3T3-L1 adipocytes. Ginkgolide C suppresses PPAR-α and PPAR-γ expression and decreases C/EBPα, C/EBPβ, and SREBP-1c expression in differentiated 3T3-L1 adipocytes. In addition, Ginkgolide C (3-100 μM) suppress adipogenesis-related protein (FAS, LPL, and aP2) and mRNA expression in a dose-dependent manner in differentiated 3T3-L1 adipocytes. Ginkgolide C (3-100 μM) also significantly promotes Sirt1 production and increases phosphorylation of AMPKα and ACC-1 in a concentration-dependent manner[1]. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets[2].
Cell Assay	3T3-L1 cells are treated with various concentrations of ginkgolide C in 96-well plates for 24 h. Cell viability is analyzed by the MTT assay. The culture medium is removed, and the cells are incubated with 100 μL MTT solution (5 mg/mL) for 4 h at 37°C. After plates are washed, isopropanol is added to dissolve formazone crystals, followed by absorbance detection with a spectrophotometer at 570 nm[1].
References	[1]. Liou CJ, et al. Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway. Evid Based Complement Alternat Med. 2015;2015:298635. [2]. Ginkgolide C, et al. Ginkgolide C inhibits platelet aggregation in cAMP- and cGMP-dependent manner by activating MMP-9. Biol Pharm Bull. 2007 Dec;30(12):2340-4.

Density	1.7±0.1 g/cm3
Boiling Point	813.8±65.0 °C at 760 mmHg
Melting Point	>3000ºC
Molecular Formula	C₂₀H₂₄O₁₁
Molecular Weight	440.398
Flash Point	291.4±27.8 °C
Exact Mass	440.131866
PSA	169.05000
LogP	0.16
Vapour Pressure	0.0±6.6 mmHg at 25°C
Index of Refraction	1.671
Storage condition	-20°C

Ginkgolide C MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

10-benzyloxy-gi...

CAS#:502421-88-7

~95%

Ginkgolide C

CAS#:15291-76-6

Literature: Jaracz, Stanislav; Malik, Shahid; Nakanishi, Koji Phytochemistry, 2004 , vol. 65, # 21 SPEC. ISS. p. 2897 - 2902

Precursor 1
CAS#:502421-88-7 10-benzyloxy-gi...
DownStream 1
CAS#:15291-77-7 Ginkgolide B

Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.

Toxicol. Sci. 139(2) , 338-49, (2014)

Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex m...

Ginkgolid C

MFCD02094178

(1R,3R,7S,8S,9R,10S,11R,13S,16S,17R)-8-tert-Butyl-6,9,12,17-tetrahydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione

(1R,3R,7S,8S,9R,10S,11R,13S,16S,17R)-6,9,12,17-Tetrahydroxy-16-methyl-8-(2-methyl-2-propanyl)-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione

6H-9,4a-(Epoxymethano)-3aH,9H-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H)-trione, 11-(1,1-dimethylethyl)hexahydro-1,4b,8,10-tetrahydroxy-5-methyl-, (3aR,4aR,4bR,5S,7aS,8aR,9S,10R,11S,11aS)-

1,7-DIHYDROXY-GINKGOLIDE A

Gingkolide C

1,3,7,10-Tetrahydroxyginkgolid

GinkgolideC

BioBioPha
China
Product Name: Ginkgolide C
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ginkgolide C
Price: ￥378.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Ginkgolide C
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ginkgolide C
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

Ginkgolide C suppliers

Price: $112/10mM*1mLinDMSO

Reference only. check more Ginkgolide C price

Ginkgolide C

Use of Ginkgolide C

Names

Ginkgolide C Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Articles1

Synonyms