U 93631
Modify Date: 2024-02-01 13:33:04
U 93631 structure
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Common Name | U 93631 | ||
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| CAS Number | 152273-12-6 | Molecular Weight | 299.36800 | |
| Density | 1.19g/cm3 | Boiling Point | 470.1ºC at 760 mmHg | |
| Molecular Formula | C17H21N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 238.1ºC | |
Use of U 93631U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors. target: GABAA receptorIC 50: GABAA receptor[1]In vitro: In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization,rather than acting as an open channel blocker. [1] |
| Name | tert-butyl 4,4-dimethyl-5H-imidazo[1,5-a]quinoxaline-3-carboxylate |
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| Synonym | More Synonyms |
| Description | U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors. target: GABAA receptorIC 50: GABAA receptor[1]In vitro: In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization,rather than acting as an open channel blocker. [1] |
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| Related Catalog | |
| References |
| Density | 1.19g/cm3 |
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| Boiling Point | 470.1ºC at 760 mmHg |
| Molecular Formula | C17H21N3O2 |
| Molecular Weight | 299.36800 |
| Flash Point | 238.1ºC |
| Exact Mass | 299.16300 |
| PSA | 56.15000 |
| LogP | 3.62620 |
| Vapour Pressure | 5.2E-09mmHg at 25°C |
| Index of Refraction | 1.598 |
| Storage condition | 2-8℃ |
| U 93631 |
| U93631 |