amfonelic acid

Modify Date: 2024-01-02 16:15:36

amfonelic acid Structure
amfonelic acid structure
Common Name amfonelic acid
CAS Number 15180-02-6 Molecular Weight 308.33
Density 1.3±0.1 g/cm3 Boiling Point 499.3±45.0 °C at 760 mmHg
Molecular Formula C18H16N2O3 Melting Point N/A
MSDS N/A Flash Point 255.8±28.7 °C

 Use of amfonelic acid


Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter[1].

 Names

Name 7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
Synonym More Synonyms

 amfonelic acid Biological Activity

Description Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter[1].
Related Catalog
References

[1]. Aceto MD, et al. Pharmacologic properties and mechanism of action of amfonelic acid. Eur J Pharmacol. 1970;10(3):344-54.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 499.3±45.0 °C at 760 mmHg
Molecular Formula C18H16N2O3
Molecular Weight 308.33
Flash Point 255.8±28.7 °C
Exact Mass 308.116089
PSA 72.19000
LogP 2.72
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.630

 Safety Information

Hazard Codes Xi
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-
amfonelic acid
7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Amfonelinsaeure
7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carbonsaeure
7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
1-Ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic Acid
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