amfonelic acid

Names

[ Name ]:
amfonelic acid

[Synonym ]:
1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-
amfonelic acid
7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Amfonelinsaeure
7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carbonsaeure
7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
1-Ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic Acid

Biological Activity

[Description]:

Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Aceto MD, et al. Pharmacologic properties and mechanism of action of amfonelic acid. Eur J Pharmacol. 1970;10(3):344-54.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
499.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₆N₂O₃

[ Molecular Weight ]:
308.33

[ Flash Point ]:
255.8±28.7 °C

[ Exact Mass ]:
308.116089

[ PSA ]:
72.19000

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.630

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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