CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UG0350000
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CHEMICAL NAME :
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Propionitrile, 3-amino-
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CAS REGISTRY NUMBER :
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151-18-8
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BEILSTEIN REFERENCE NO. :
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1698848
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LAST UPDATED :
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199701
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DATA ITEMS CITED :
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9
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MOLECULAR FORMULA :
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C3-H6-N2
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MOLECULAR WEIGHT :
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70.11
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WISWESSER LINE NOTATION :
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Z2CN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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12800 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1152 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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10 gm/kg/11D-I
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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5 gm/kg
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SEX/DURATION :
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female 14-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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1250 mg/kg
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SEX/DURATION :
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female 10 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1250 mg/kg
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SEX/DURATION :
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female 11 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Rodent - mouse Embryo
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DOSE/DURATION :
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1250 mg/kg
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REFERENCE :
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ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,305,1981
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