BC-1215
Modify Date: 2025-09-04 12:00:12
BC-1215 structure
|
Common Name | BC-1215 | ||
|---|---|---|---|---|
| CAS Number | 1507370-20-8 | Molecular Weight | 394.511 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 589.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C26H26N4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 310.6±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BC-1215BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215, interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC[1]. |
| Name | N,N'-Bis[4-(2-pyridinyl)benzyl]-1,2-ethanediamine |
|---|---|
| Synonym | More Synonyms |
| Description | BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215, interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 589.9±50.0 °C at 760 mmHg |
| Molecular Formula | C26H26N4 |
| Molecular Weight | 394.511 |
| Flash Point | 310.6±30.1 °C |
| Exact Mass | 394.215759 |
| LogP | 3.68 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.613 |
| InChIKey | IXEPQJQQSLMESJ-UHFFFAOYSA-N |
| SMILES | c1ccc(-c2ccc(CNCCNCc3ccc(-c4ccccn4)cc3)cc2)nc1 |
| N,N'-Bis[4-(2-pyridinyl)benzyl]-1,2-ethanediamine |
| MFCD28118991 |
| 1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]- |