1507370-20-8
1507370-20-8 structure
- Name: BC-1215
- Chemical Name: N,N'-Bis[4-(2-pyridinyl)benzyl]-1,2-ethanediamine
- CAS Number: 1507370-20-8
- Molecular Formula: C26H26N4
- Molecular Weight: 394.511
- Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
- Create Date: 2018-07-07 05:18:50
- Modify Date: 2025-09-04 12:00:12
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BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215, interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC[1].
| Name | N,N'-Bis[4-(2-pyridinyl)benzyl]-1,2-ethanediamine |
|---|---|
| Synonyms |
N,N'-Bis[4-(2-pyridinyl)benzyl]-1,2-ethanediamine
MFCD28118991 1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]- |
| Description | BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215, interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 589.9±50.0 °C at 760 mmHg |
| Molecular Formula | C26H26N4 |
| Molecular Weight | 394.511 |
| Flash Point | 310.6±30.1 °C |
| Exact Mass | 394.215759 |
| LogP | 3.68 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.613 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |