534579-04-9
534579-04-9 structure
- Name: BC-54
- Chemical Name: BC-54
- CAS Number: 534579-04-9
- Molecular Formula: C22H24N4O4
- Molecular Weight: 408.458
- Create Date: 2020-01-11 20:42:50
- Modify Date: 2024-09-20 13:15:00
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A potent and biologically-active PDE4/7 inhibitor with IC50 of 50-100 nM for PDE4A/B/D, and 140 nM for both PDE7A/B; showed only modest activity (IC50=3 uM) against PDE2A and PDE11A, and little to no activity (IC50 >10 uM) against PDE1C/3B/5A /8A/9A/10A; displays exceptional anti-inflammatory activity and induces apoptosis in CLL cells.
| Name | BC-54 |
|---|
| Description | A potent and biologically-active PDE4/7 inhibitor with IC50 of 50-100 nM for PDE4A/B/D, and 140 nM for both PDE7A/B; showed only modest activity (IC50=3 uM) against PDE2A and PDE11A, and little to no activity (IC50 >10 uM) against PDE1C/3B/5A /8A/9A/10A; displays exceptional anti-inflammatory activity and induces apoptosis in CLL cells. |
|---|---|
| References | References 1. de Medeiros AS, et al. Cell Signal. 2017 Sep 1;40:73-80. View Related Products by Target Phosphodiesterase (PDE) |
| Molecular Formula | C22H24N4O4 |
|---|---|
| Molecular Weight | 408.458 |