BC-1382
Modify Date: 2024-01-13 12:35:22
BC-1382 structure
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Common Name | BC-1382 | ||
|---|---|---|---|---|
| CAS Number | 1013753-99-5 | Molecular Weight | 459.559 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H29N3O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BC-1382A potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM; drastically increases PIAS1 protein level with IC50 of 100 nM and improves PIAS1 protein stability, with no effect on PIAS3, PIAS4, and HECTD2 protein levels; suppresses LPS-induced PIAS1 degradation and restores PIAS1 protein levels at 800 nM, and proinflammatory cytokines released by PBMCs; attenuates LPS- and Pseudomonas aeruginosa-induced lung inflammation |
| Name | N-{(2S)-1-[(2-Methoxybenzyl)amino]-1-oxo-2-propanyl}-1-(phenylsulfonyl)-4-piperidinecarboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | A potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM; drastically increases PIAS1 protein level with IC50 of 100 nM and improves PIAS1 protein stability, with no effect on PIAS3, PIAS4, and HECTD2 protein levels; suppresses LPS-induced PIAS1 degradation and restores PIAS1 protein levels at 800 nM, and proinflammatory cytokines released by PBMCs; attenuates LPS- and Pseudomonas aeruginosa-induced lung inflammation |
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| References | References 1. Coon TA, et al. Sci Transl Med. 2015 Jul 8;7(295):295ra109. View Related Products by Target E3 Ubiquitin Ligase |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H29N3O5S |
| Molecular Weight | 459.559 |
| Exact Mass | 459.182800 |
| LogP | 2.13 |
| Index of Refraction | 1.584 |
| Hazard Codes | Xi |
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| 4-Piperidinecarboxamide, N-[(1S)-2-[[(2-methoxyphenyl)methyl]amino]-1-methyl-2-oxoethyl]-1-(phenylsulfonyl)- |
| N-{(2S)-1-[(2-Methoxybenzyl)amino]-1-oxo-2-propanyl}-1-(phenylsulfonyl)-4-piperidinecarboxamide |
| MFCD08290616 |
| MFCD30470656 |