Tankyrase-IN-5

Modify Date: 2024-04-06 19:19:49

Tankyrase-IN-5 structure	Common Name	Tankyrase-IN-5
	CAS Number	1460285-69-1	Molecular Weight	282.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₈N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tankyrase-IN-5

Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1].

Name	Tankyrase-IN-5

Description	Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	IC50: 2.3 nM (TNKS1), 7.9 nM (TNKS2), 1900 nM (PARP1)[1]
References	[1]. Buchstaller HP, et al. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 22;64(14):10371-10392.

Molecular Formula	C₁₇H₁₈N₂O₂
Molecular Weight	282.34

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