Tankyrase-IN-5

Names

[ CAS No. ]:
1460285-69-1

[ Name ]:
Tankyrase-IN-5

Biological Activity

[Description]:

Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> PARP
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

IC50: 2.3 nM (TNKS1), 7.9 nM (TNKS2), 1900 nM (PARP1)[1]


[References]

[1]. Buchstaller HP, et al. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 22;64(14):10371-10392.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H18N2O2

[ Molecular Weight ]:
282.34

Related Compounds

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