A 77636 hydrochloride

Modify Date: 2025-08-26 22:35:52

A 77636 hydrochloride Structure
A 77636 hydrochloride structure
 Common Name A 77636 hydrochloride
CAS Number 145307-34-2 Molecular Weight 365.89400
Density N/A Boiling Point 515.3ºC at 760 mmHg
Molecular Formula C20H28ClNO3 Melting Point N/A
MSDS Chinese USA Flash Point 265.5ºC

 Use of A 77636 hydrochloride


A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].

 Names

Name (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
Synonym More Synonyms

 A 77636 hydrochloride Biological Activity

Description A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].
Related Catalog
In Vivo A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration[3]. Animal Model: Male hooded rat[1] Dosage: 0.1, 0.3 and 1.0 mg/kg Administration: S.c. Result: Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.
References

[1]. Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229(2-3):203-209.

[2]. Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna). 2002;109(2):123-140.

[3]. Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532(3):253-257.

 Chemical & Physical Properties

Boiling Point 515.3ºC at 760 mmHg
Molecular Formula C20H28ClNO3
Molecular Weight 365.89400
Flash Point 265.5ºC
Exact Mass 365.17600
PSA 75.71000
LogP 4.75760
Vapour Pressure 3.06E-11mmHg at 25°C
Storage condition -20°C

 Synonyms

A-77636 hydrochloride hydrate
(1R,3S)-3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride
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