A 77636 hydrochloride
Modify Date: 2024-01-13 18:21:08
A 77636 hydrochloride structure
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Common Name | A 77636 hydrochloride | ||
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| CAS Number | 145307-34-2 | Molecular Weight | 365.89400 | |
| Density | N/A | Boiling Point | 515.3ºC at 760 mmHg | |
| Molecular Formula | C20H28ClNO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 265.5ºC | |
Use of A 77636 hydrochlorideA-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2]. |
| Name | (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride |
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| Synonym | More Synonyms |
| Description | A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2]. |
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| Related Catalog | |
| In Vivo | A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration[3]. Animal Model: Male hooded rat[1] Dosage: 0.1, 0.3 and 1.0 mg/kg Administration: S.c. Result: Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration. |
| References |
| Boiling Point | 515.3ºC at 760 mmHg |
|---|---|
| Molecular Formula | C20H28ClNO3 |
| Molecular Weight | 365.89400 |
| Flash Point | 265.5ºC |
| Exact Mass | 365.17600 |
| PSA | 75.71000 |
| LogP | 4.75760 |
| Vapour Pressure | 3.06E-11mmHg at 25°C |
| Storage condition | -20°C |
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~81%
A 77636 hydroch... CAS#:145307-34-2 |
| Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118 |
|
~%
A 77636 hydroch... CAS#:145307-34-2 |
| Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118 |
|
~%
A 77636 hydroch... CAS#:145307-34-2 |
| Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118 |
|
~%
A 77636 hydroch... CAS#:145307-34-2 |
| Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118 |
| A-77636 hydrochloride hydrate |
| (1R,3S)-3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride |