145307-34-2

145307-34-2 structure

Name: A 77636 hydrochloride
Chemical Name: (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
CAS Number: 145307-34-2
Molecular Formula: C₂₀H₂₈ClNO₃
Molecular Weight: 365.89400
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-02-20 08:00:00
Modify Date: 2024-01-13 18:21:08
A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].

Name	(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
Synonyms	A-77636 hydrochloride hydrate (1R,3S)-3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

Description	A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vivo	A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration[3]. Animal Model: Male hooded rat[1] Dosage: 0.1, 0.3 and 1.0 mg/kg Administration: S.c. Result: Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.
References	[1]. Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229(2-3):203-209. [2]. Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna). 2002;109(2):123-140. [3]. Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532(3):253-257.

145238-47-7

~81%

145307-34-2

Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118

145238-40-0

145307-34-2

Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118

145238-42-2

145307-34-2

Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118

145238-44-4

145307-34-2

Literature: DeNinno; Perner; Morton; DiDomenico Jr. Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7115 - 7118