A 77636 hydrochloride

Names

[ Name ]:
A 77636 hydrochloride

[Synonym ]:
A-77636 hydrochloride hydrate
(1R,3S)-3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

Biological Activity

[Description]:

A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[In Vivo]

A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration[3]. Animal Model: Male hooded rat[1] Dosage: 0.1, 0.3 and 1.0 mg/kg Administration: S.c. Result: Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.

[References]

[1]. Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229(2-3):203-209.

[2]. Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna). 2002;109(2):123-140.

[3]. Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532(3):253-257.

Chemical & Physical Properties

[ Boiling Point ]:
515.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₈ClNO₃

[ Molecular Weight ]:
365.89400

[ Flash Point ]:
265.5ºC

[ Exact Mass ]:
365.17600

[ PSA ]:
75.71000

[ LogP ]:
4.75760

[ Vapour Pressure ]:
3.06E-11mmHg at 25°C

[ Storage condition ]:
-20°C

MSDS

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Synthetic Route

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Related Compounds

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