T247
Modify Date: 2024-01-21 18:41:13
T247 structure
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Common Name | T247 | ||
|---|---|---|---|---|
| CAS Number | 1451042-18-4 | Molecular Weight | 389.47 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H19N5OS | Melting Point | 236 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of T247HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1]. |
| Name | N-(2-Aminophenyl)-4-{1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl}benzamide |
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| Synonym | More Synonyms |
| Description | HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1]. |
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| Related Catalog | |
| Target |
HDAC3:0.24 μM (IC50) HDAC1:19 μM (IC50) HDAC4:>100 μM (IC50) HDAC6:>100 μM (IC50) HDAC8:>100 μM (IC50) |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Melting Point | 236 °C |
| Molecular Formula | C21H19N5OS |
| Molecular Weight | 389.47 |
| Exact Mass | 389.131042 |
| LogP | 2.58 |
| Index of Refraction | 1.706 |
| Benzamide, N-(2-aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]- |
| N-(2-Aminophenyl)-4-{1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl}benzamide |
| T247 |