1451042-18-4

1451042-18-4 structure

Name: T247
Chemical Name: N-(2-Aminophenyl)-4-{1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl}benzamide
CAS Number: 1451042-18-4
Molecular Formula: C₂₁H₁₉N₅OS
Molecular Weight: 389.47
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2018-02-26 17:50:23
Modify Date: 2024-01-21 18:41:13
HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1].

Name	N-(2-Aminophenyl)-4-{1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl}benzamide
Synonyms	Benzamide, N-(2-aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]- N-(2-Aminophenyl)-4-{1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl}benzamide T247

Description	HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC3:0.24 μM (IC50) HDAC1:19 μM (IC50) HDAC4:>100 μM (IC50) HDAC6:>100 μM (IC50) HDAC8:>100 μM (IC50)
References	[1]. Suzuki T, et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 2013 Jul 16;8(7):e68669.