T247

Names

[ Name ]:
T247

[Synonym ]:
Benzamide, N-(2-aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]-
N-(2-Aminophenyl)-4-{1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl}benzamide
T247

Biological Activity

[Description]:

HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC3:0.24 μM (IC50)

HDAC1:19 μM (IC50)

HDAC4:>100 μM (IC50)

HDAC6:>100 μM (IC50)

HDAC8:>100 μM (IC50)

[References]

[1]. Suzuki T, et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 2013 Jul 16;8(7):e68669.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
236 °C

[ Molecular Formula ]:
C₂₁H₁₉N₅OS

[ Molecular Weight ]:
389.47

[ Exact Mass ]:
389.131042

[ LogP ]:
2.58

[ Index of Refraction ]:
1.706