Opiranserin

Modify Date: 2024-01-06 11:52:27

Opiranserin structure	Common Name	Opiranserin
	CAS Number	1441000-45-8	Molecular Weight	394.505
	Density	1.1±0.1 g/cm3	Boiling Point	489.0±45.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₄N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	249.6±28.7 °C

Use of Opiranserin

Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM); demonstrates analgesic efficacy for postoperative pain. Pain Phase 2 Clinical

Name	opiranserin
Synonym	More Synonyms

Description	Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM); demonstrates analgesic efficacy for postoperative pain. Pain Phase 2 Clinical
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> GlyT
Target	5-HT2A Receptor:1.3 μM (IC50) GlyT2:0.86 μM (IC50) rP2X3:0.87 μM (IC50)
References	[1]. Oh J, et al. Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study. J Clin Pharmacol. 2018 Jan;58(1):64-73. [2]. Nedeljkovic SS, et al. Randomised, double-blind, parallel group, placebo-controlled study to evaluate the analgesic efficacy and safety of VVZ-149 injections for postoperative pain following laparoscopic colorectal surgery. BMJ Open. 2017 Feb 17;7(2):e011035. [3]. Pang MH, et al. A series of case studies: practical methodology for identifying antinociceptive multi-target drugs. Drug Discov Today. 2012 May;17(9-10):425-34.

Density	1.1±0.1 g/cm3
Boiling Point	489.0±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₄N₂O₅
Molecular Weight	394.505
Flash Point	249.6±28.7 °C
Exact Mass	394.246765
LogP	1.88
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.532

4-Butoxy-N-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-3,5-dimethoxybenzamide

Benzamide, 4-butoxy-N-[[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl]-3,5-dimethoxy-

opiranserin

Opiranserin

Use of Opiranserin

Names

Opiranserin Biological Activity

Chemical & Physical Properties

Synonyms