1440796-75-7

1440796-75-7 structure
1440796-75-7 structure
  • Name: Opiranserin hydrochloride
  • Chemical Name: Opiranserin hydrochloride
  • CAS Number: 1440796-75-7
  • Molecular Formula: C21H35ClN2O5
  • Molecular Weight: 430.97
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2022-07-11 11:43:23
  • Modify Date: 2024-01-11 04:13:37
  • Opiranserin (VVZ-149) hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain[1][2][3].

Name Opiranserin hydrochloride
Description Opiranserin (VVZ-149) hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain[1][2][3].
Related Catalog
Target

GlyT2:0.86 μM (IC50)

5-HT2A Receptor:1.3 μM (IC50)

rP2X3:0.87 μM (IC50)

References

[1]. Oh J, et al. Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study. J Clin Pharmacol. 2018 Jan;58(1):64-73.

[2]. Nedeljkovic SS, et al. Randomised, double-blind, parallel group, placebo-controlled study to evaluate the analgesic efficacy and safety of VVZ-149 injections for postoperative pain following laparoscopic colorectal surgery. BMJ Open. 2017 Feb 17;7(2):e011035.

[3]. Pang MH, et al. A series of case studies: practical methodology for identifying antinociceptive multi-target drugs. Drug Discov Today. 2012 May;17(9-10):425-34.

Molecular Formula C21H35ClN2O5
Molecular Weight 430.97