Ro 41-3290

Modify Date: 2025-08-27 10:30:05

Ro 41-3290 structure	Common Name	Ro 41-3290
	CAS Number	143943-72-0	Molecular Weight	420.888
	Density	1.4±0.1 g/cm3	Boiling Point	723.3±60.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₁ClN₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	391.2±32.9 °C

Use of Ro 41-3290

Ro 41-3290 is the desethylated derivative of Ro 41-3696, which is a nonbenzodiazepine partial agonist at the benzodiazepine receptor. Ro 41-3290 is an investigational hypnotic.

Name	Ro 41-3290
Synonym	More Synonyms

Description	Ro 41-3290 is the desethylated derivative of Ro 41-3696, which is a nonbenzodiazepine partial agonist at the benzodiazepine receptor. Ro 41-3290 is an investigational hypnotic.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease
Target	Benzodiazepine receptor[1]
In Vivo	At all times plasma levels of Ro 41-3290, the desethylated derivative of Ro 41-3696, are higher than those of the parent drug (tmax and t1/2 values=~2 and 8 hours, respectively)[1]. Pharmacokinetics of both Ro 41-3696 and its O-desethyl metabolite Ro 41-3290 are dose proportional and time independent. Ro 41-3696 is absorbed and eliminates rapidly (time of maximum plasma concentration, approximately 1 hour; elimination half-life, approximately 2 hours). Plasma levels of Ro 41-3290 are higher than those of the parent drug, and it is more slowly eliminated (values for time of maximum plasma concentration and elimination half-life, approximately 2 and approximately 7 hours, respectively)[2].
References	[1]. Dingemanse J, et al. Pharmacokinetics and pharmacodynamics of Ro 41-3696, a novel nonbenzodiazepine hypnotic. J Clin Pharmacol. 1995 Aug;35(8):821-9. [2]. Dingemanse J, et al. Multiple-dose tolerability, pharmacodynamics, and pharmacokinetics of the quinolizinone hypnotic Ro 41-3696 in elderly subjects. Clin Neuropharmacol. 2001 Mar-Apr;24(2):82-90.

Density	1.4±0.1 g/cm3
Boiling Point	723.3±60.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₁ClN₂O₃
Molecular Weight	420.888
Flash Point	391.2±32.9 °C
Exact Mass	420.124084
LogP	3.00
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.717

4H-Benzo[a]quinolizin-4-one, 10-chloro-6,7-dihydro-1-[[(3S)-3-hydroxy-1-pyrrolidinyl]carbonyl]-3-phenyl-

EIR1Q66583

10-Chloro-1-{[(3S)-3-hydroxy-1-pyrrolidinyl]carbonyl}-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinolin-4-one

RO-41-3290

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Shanghai Nianxing Industrial Co., Ltd
China
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Ro 41-3290

Use of Ro 41-3290

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Ro 41-3290 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.