Diprenorphine

Modify Date: 2024-01-04 19:06:21

Diprenorphine structure	Common Name	Diprenorphine
	CAS Number	14357-78-9	Molecular Weight	425.56000
	Density	1.33 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₅NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Diprenorphine

Diprenorphine is a non-selective opioid antagonist with Ki values of 0.017, 0.072 and 0.23 nM against κ-, μ- and δ-opioid receptors, respectively[1]. Diprenorphine can be used for central poststroke pain (CPSP) research[1].

Name	Diprenorphine,17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
Synonym	More Synonyms

Description	Diprenorphine is a non-selective opioid antagonist with Ki values of 0.017, 0.072 and 0.23 nM against κ-, μ- and δ-opioid receptors, respectively[1]. Diprenorphine can be used for central poststroke pain (CPSP) research[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	Ki: 0.017 nM (κ-opioid receptor), 0.072 nM (μ-opioid receptor), 0.23 nM (δ-opioid receptor)[1]
References	[1]. Raynor K, et al. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4. [2]. Willoch F, et al. Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study. Pain. 2004 Apr;108(3):213-220.

Density	1.33 g/cm3
Molecular Formula	C₂₆H₃₅NO₄
Molecular Weight	425.56000
Exact Mass	425.25700
PSA	62.16000
LogP	3.32550
Index of Refraction	1.656

Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22

Precursor 5
CAS#:1489-69-6 Cyclopropanecar... CAS#:2579-67-1 17-Northebaine CAS#:16528-12-4 (5R,6R,7S,9R,13... CAS#:74-88-4 methyl iodide
CAS#:72221-15-9 N-Benzyl-northebain
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