Diprenorphine

Names

[ Name ]:
Diprenorphine

[Synonym ]:
DIPRENORPHINE
RX-5050M
Diprenorphin
DIPRENORPHINE POTENT OPIOID ANTAGON
diprenorpine
M-5050

Biological Activity

[Description]:

Diprenorphine is a non-selective opioid antagonist with Ki values of 0.017, 0.072 and 0.23 nM against κ-, μ- and δ-opioid receptors, respectively[1]. Diprenorphine can be used for central poststroke pain (CPSP) research[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[Target]

Ki: 0.017 nM (κ-opioid receptor), 0.072 nM (μ-opioid receptor), 0.23 nM (δ-opioid receptor)[1]

[References]

[1]. Raynor K, et al. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4.

[2]. Willoch F, et al. Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study. Pain. 2004 Apr;108(3):213-220.

Chemical & Physical Properties

[ Density]:
1.33 g/cm3

[ Molecular Formula ]:
C₂₆H₃₅NO₄

[ Molecular Weight ]:
425.56000

[ Exact Mass ]:
425.25700

[ PSA ]:
62.16000

[ LogP ]:
3.32550

[ Index of Refraction ]:
1.656

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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