4-Bromo-3-hydroxybenzoic acid

Modify Date: 2024-01-09 13:02:12

4-Bromo-3-hydroxybenzoic acid structure	Common Name	4-Bromo-3-hydroxybenzoic acid
	CAS Number	14348-38-0	Molecular Weight	217.017
	Density	1.9±0.1 g/cm3	Boiling Point	338.6±32.0 °C at 760 mmHg
	Molecular Formula	C₇H₅BrO₃	Melting Point	225-227ºC
	MSDS	N/A	Flash Point	158.6±25.1 °C

Use of 4-Bromo-3-hydroxybenzoic acid

4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes[1][2].

Name	4-Bromo-3-hydroxybenzoic acid
Synonym	More Synonyms

Description	4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes[1][2].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	IC50: 1 mM (Rat fetal histidine decarboxylase (HDC)), 1 mM (Ratgastric HDC), 1 mM (Hog kidney aromatic-L-amino acid decarboxylase), 1 mM (Rat gastric mucosa aromatic-L-amino acid decarboxylase)[1]
References	[1]. Ellenbogen L, et al. Studies on the inhibition of histidine decarboxylase, aromatic-L-amino acid decarboxylase and acid secretion by brocresine and its metabolites. Biochem Pharmacol. 1973 Apr 15;22(8):939-47. [2]. Qian S, et al. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019 Mar;67(3):411-417.

Density	1.9±0.1 g/cm3
Boiling Point	338.6±32.0 °C at 760 mmHg
Melting Point	225-227ºC
Molecular Formula	C₇H₅BrO₃
Molecular Weight	217.017
Flash Point	158.6±25.1 °C
Exact Mass	215.942200
PSA	57.53000
LogP	2.68
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.655

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: 4-Bromo-3-hydroxybenzoic acid
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:4-Bromo-3-hydroxybenzoic acid
CAS number:14348-38-0

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C7H5BrO3
Molecular weight:217.0

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen bromide.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

Hazard Codes	Xi: Irritant;
HS Code	2918290000

Precursor 9
CAS#:99-06-9 3-Hydroxybenzoicacid CAS#:2374-03-0 4-Amino-3-hydro... CAS#:56256-14-5 4-Bromo-3-metho... CAS#:22921-68-2 2-Bromo-5-metho...
CAS#:7726-95-6 Bromine CAS#:56-23-5 Carbon tetrachloride CAS#:67-66-3 Chloroform CAS#:64-19-7 acetic acid
CAS#:10035-10-6 Hydrogen bromide
DownStream 6
CAS#:99-50-3 protocatechuic acid CAS#:106291-80-9 Methyl 4-bromo-... CAS#:33141-66-1 Ethyl 4-bromo-3... CAS#:17054-27-2 3-(BENZYLOXY)-4...
CAS#:247186-50-1 TERT-BUTYL 3-(B... CAS#:17100-63-9 Methyl 4-bromo-...

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%