4-Bromo-3-hydroxybenzoic acid

Names

[ Name ]:
4-Bromo-3-hydroxybenzoic acid

[Synonym ]:
4-Bromo-3-hydroxybenzoic acid
Benzoic acid, 4-bromo-3-hydroxy-

Biological Activity

[Description]:

4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

IC50: 1 mM (Rat fetal histidine decarboxylase (HDC)), 1 mM (Ratgastric HDC), 1 mM (Hog kidney aromatic-L-amino acid decarboxylase), 1 mM (Rat gastric mucosa aromatic-L-amino acid decarboxylase)[1]

[References]

[1]. Ellenbogen L, et al. Studies on the inhibition of histidine decarboxylase, aromatic-L-amino acid decarboxylase and acid secretion by brocresine and its metabolites. Biochem Pharmacol. 1973 Apr 15;22(8):939-47.

[2]. Qian S, et al. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019 Mar;67(3):411-417.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
338.6±32.0 °C at 760 mmHg

[ Melting Point ]:
225-227ºC

[ Molecular Formula ]:
C₇H₅BrO₃

[ Molecular Weight ]:
217.017

[ Flash Point ]:
158.6±25.1 °C

[ Exact Mass ]:
215.942200

[ PSA ]:
57.53000

[ LogP ]:
2.68

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.655

MSDS

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Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ HS Code ]:
2918290000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%