protocatechuic acid
Names
[ CAS No. ]:
99-50-3
[ Name ]:
protocatechuic acid
[Synonym ]:
MFCD00002509
3,4-dihydroxy-benzoic acid
4,5-Dihydroxybenzoic acid
3,4-Dihydroxybenzoic acid
4-Carboxy-1,2-dihydroxybenzene
Protocatehuic acid
protocatechuate
EINECS 202-760-0
Benzoic acid, 3,4-dihydroxy-
protochatechuic acid
protocatechuic acid
3,4-dihydroxybenzoate
Benzoic acid,3,4-dihydroxy
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
410.7±35.0 °C at 760 mmHg
[ Melting Point ]:
197-200 °C (dec.)(lit.)
[ Molecular Formula ]:
C7H6O4
[ Molecular Weight ]:
154.120
[ Flash Point ]:
216.3±22.4 °C
[ Exact Mass ]:
154.026611
[ PSA ]:
77.76000
[ LogP ]:
1.16
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.671
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UL0560000
- CHEMICAL NAME :
- Protocatechuic acid
- CAS REGISTRY NUMBER :
- 99-50-3
- BEILSTEIN REFERENCE NO. :
- 1448841
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C7-H6-O4
- MOLECULAR WEIGHT :
- 154.13
- WISWESSER LINE NOTATION :
- QVR CQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 3 gm/L
- REFERENCE :
- CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UL0560000
[ HS Code ]:
2918290000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918290000
[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
Articles
Pharm. Biol. 53(6) , 800-6, (2015)
The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...
Antioxidant activity of protocatechuates evaluated by DPPH, ORAC, and CAT methods.Food Chem. 194 , 749-57, (2015)
Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natura...
Effect of selected Saccharomyces cerevisiae yeast strains and different aging techniques on the polysaccharide and polyphenolic composition and sensorial characteristics of Cabernet Sauvignon red wines.J. Sci. Food Agric. 95 , 2132-44, (2015)
The objective of this work was to study the effect of two Saccharomyces cerevisiae yeast strains with different capabilities of polysaccharide liberation during alcoholic fermentation in addition to s...