Me-PEG4-Me

Modify Date: 2025-08-20 19:58:28

Me-PEG4-Me structure	Common Name	Me-PEG4-Me
	CAS Number	143-24-8	Molecular Weight	222.279
	Density	1.0±0.1 g/cm3	Boiling Point	275.3±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₂₂O₅	Melting Point	−30 °C(lit.)
	MSDS	Chinese USA	Flash Point	140.6±0.0 °C
	Symbol	GHS08	Signal Word	Danger

Use of Me-PEG4-Me

Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	tetraglyme
Synonym	More Synonyms

Description	Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.0±0.1 g/cm3
Boiling Point	275.3±0.0 °C at 760 mmHg
Melting Point	−30 °C(lit.)
Molecular Formula	C₁₀H₂₂O₅
Molecular Weight	222.279
Flash Point	140.6±0.0 °C
Exact Mass	222.146729
PSA	46.15000
LogP	-1.51
Vapour density	7.7 (vs air)
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.421

Me-PEG4-Me MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SB0400000

CHEMICAL NAME :: 2,5,8,11,14-Pentaoxapentadecane

CAS REGISTRY NUMBER :: 143-24-8

BEILSTEIN REFERENCE NO. :: 1760005

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H22-O5

MOLECULAR WEIGHT :: 222.32

WISWESSER LINE NOTATION :: 1O2O2O2O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5140 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360Df
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R19;R43
Safety Phrases	S36-S24
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	SB0400000
HS Code	2942000000

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Me-PEG4-Me

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Literature: Barnakov, Ch. N.; Volgin, A. A. Russian Journal of Applied Chemistry, 1993 , vol. 66, # 1.2 p. 152 - 155 Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1993 , vol. 66, # 1 p. 182 - 185

ETHYLENE OXIDE

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~0%

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Detail

Literature: WO2005/87695 A1, ; Page/Page column 7-9 ;

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Me-PEG4-Me

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Literature: Bulletin de la Societe Chimique de France, , p. 844,846 Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 54, p. 421,424

dimethyl ether

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Me-PEG4-Me

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Literature: WO2006/134081 A1, ; Page/Page column 6 ;

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Me-PEG4-Me

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Literature: Industrial and Engineering Chemistry, , vol. 29, p. 548 Chem. Zentralbl., , vol. 109, # I p. 4534 US2111234 , ;

HS Code	2901100000
Summary	2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Radical Cationic Pathway for the Decay of Ionized Glyme Molecules in Liquid Solution.

J. Phys. Chem. B 119 , 14472-8, (2015)

Chemical stability of primary radical cations (RCs) generated in irradiated matter determines substantially the radiation resistance of organic materials. Transformations of the RCs of the glyme molec...

Development of bipolar all-solid-state lithium battery based on quasi-solid-state electrolyte containing tetraglyme-LiTFSA equimolar complex.

Sci. Rep. 5 , 8869, (2015)

The development of high energy-density lithium-ion secondary batteries as storage batteries in vehicles is attracting increasing attention. In this study, high-voltage bipolar stacked batteries with a...

Mechanism and Kinetics of Li2S Precipitation in Lithium-Sulfur Batteries.

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The kinetics of Li2 S electrodeposition onto carbon in lithium-sulfur batteries are characterized. Electrodeposition is found to be dominated by a 2D nucleation and growth process with rate constants ...

tetraglyme

Dimethyltetraglycol

Bis[2-(2-methoxyethoxy)ethyl] ether

MFCD00008505

2,5,8,11,14-Pentaoxapentadecane

EINECS 205-594-7

1-methoxy-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane

2,5,8,11,14-Pentaoxapentadecane (Bis[2-(2-methoxyethoxy)ethyl] ether

Dimethoxytetraethylene glycol

Tetraethylene glycol dimethyl ether

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Me-PEG4-Me
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Me-PEG4-Me
Price: ￥108.0/100ml ￥318.0/500ml ￥Inquiry/1mg
Purity: 99.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Me-PEG4-Me
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tetraethylene glycol dimethyl ether TOP1 supplier
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: tetraglyme
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Me-PEG4-Me
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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Me-PEG4-Me

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Me-PEG4-Me Biological Activity

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MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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