Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Me-PEG4-Me
Price: ￥108.0/100ml ￥318.0/500ml ￥Inquiry/1mg
Purity: 99.0%
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Contact: Liu jia

DC Chemicals Limited
China
Product Name: Me-PEG4-Me
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tetraethylene glycol dimethyl ether TOP1 supplier
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: tetraglyme
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

143-24-8

143-24-8 structure

Name: Me-PEG4-Me
Chemical Name: tetraglyme
CAS Number: 143-24-8
Molecular Formula: C₁₀H₂₂O₅
Molecular Weight: 222.279
Catalog: Chemical reagent Organic reagent Ether
Create Date: 2018-04-23 08:00:00
Modify Date: 2024-01-02 18:10:39
Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	tetraglyme
Synonyms	tetraglyme Dimethyltetraglycol Bis[2-(2-methoxyethoxy)ethyl] ether MFCD00008505 2,5,8,11,14-Pentaoxapentadecane EINECS 205-594-7 1-methoxy-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane 2,5,8,11,14-Pentaoxapentadecane (Bis[2-(2-methoxyethoxy)ethyl] ether Dimethoxytetraethylene glycol Tetraethylene glycol dimethyl ether

Description	Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.0±0.1 g/cm3
Boiling Point	275.3±0.0 °C at 760 mmHg
Melting Point	−30 °C(lit.)
Molecular Formula	C₁₀H₂₂O₅
Molecular Weight	222.279
Flash Point	140.6±0.0 °C
Exact Mass	222.146729
PSA	46.15000
LogP	-1.51
Vapour density	7.7 (vs air)
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.421

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SB0400000

CHEMICAL NAME :: 2,5,8,11,14-Pentaoxapentadecane

CAS REGISTRY NUMBER :: 143-24-8

BEILSTEIN REFERENCE NO. :: 1760005

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H22-O5

MOLECULAR WEIGHT :: 222.32

WISWESSER LINE NOTATION :: 1O2O2O2O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5140 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360Df
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R19;R43
Safety Phrases	S36-S24
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	SB0400000
HS Code	2942000000

111-77-3

143-24-8

Literature: Barnakov, Ch. N.; Volgin, A. A. Russian Journal of Applied Chemistry, 1993 , vol. 66, # 1.2 p. 152 - 155 Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1993 , vol. 66, # 1 p. 182 - 185

75-21-8

115-10-6

~0%

110-71-4

112-49-2

Detail

Literature: WO2005/87695 A1, ; Page/Page column 7-9 ;

638-56-2

124-41-4

143-24-8

Literature: Bulletin de la Societe Chimique de France, , p. 844,846 Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 54, p. 421,424

115-10-6

112-49-2

111-96-6

143-24-8

Literature: WO2006/134081 A1, ; Page/Page column 6 ;

111-44-4

143-24-8

Literature: Industrial and Engineering Chemistry, , vol. 29, p. 548 Chem. Zentralbl., , vol. 109, # I p. 4534 US2111234 , ;

HS Code	2901100000
Summary	2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

143-24-8	2828433-59-4
2829282-26-8	68037-59-2
68083-18-1	30315-93-6
308064-18-8	168216-05-5
157479-50-0	252554-79-3