1,3-Dichloropropane

Modify Date: 2024-01-02 12:19:05

1,3-Dichloropropane Structure
1,3-Dichloropropane structure
Common Name 1,3-Dichloropropane
CAS Number 142-28-9 Molecular Weight 112.986
Density 1.1±0.1 g/cm3 Boiling Point 120.4±0.0 °C at 760 mmHg
Molecular Formula C3H6Cl2 Melting Point −99 °C(lit.)
MSDS Chinese USA Flash Point 32.2±0.0 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Warning

 Names

Name 1,3-Dichloropropane
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 120.4±0.0 °C at 760 mmHg
Melting Point −99 °C(lit.)
Molecular Formula C3H6Cl2
Molecular Weight 112.986
Flash Point 32.2±0.0 °C
Exact Mass 111.984657
LogP 2.00
Vapour Pressure 18.3±0.2 mmHg at 25°C
Index of Refraction 1.422
Water Solubility 0.8 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TX9660000
CHEMICAL NAME :
Propane, 1,3-dichloro-
CAS REGISTRY NUMBER :
142-28-9
LAST UPDATED :
199712
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C3-H6-Cl2
MOLECULAR WEIGHT :
112.99
WISWESSER LINE NOTATION :
G3G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3600 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Blood - hemorrhage
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8400 mg/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
72 gm/kg/90D-I
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
6600 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Warning
Hazard Statements H226-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes F:Flammable
Risk Phrases R11;R20/22
Safety Phrases S9-S16-S29-S33-S24-S61-S26-S45-S36/37-S7
RIDADR UN 1993 3/PG 2
WGK Germany 2
RTECS TX9660000
Packaging Group II
Hazard Class 3
HS Code 2903199000

 Synthetic Route

 Customs

HS Code 2903199000
Summary 2903199000 other saturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles12

More Articles
Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropane.

Drug Metab. Dispos. 32(1) , 123-31, (2004)

Cytochrome P450-dependent oxidation and glutathione (GSH)-dependent conjugation are the primary routes of metabolism of haloalkanes. Using rat liver microsomes and cytosol, we investigated the metabol...

1,3-Dichloropropene (technical grade).

Rep. Carcinog. 10 , 91-3, (2002)

Biological effect monitoring.

Arch. Toxicol. Suppl. 15 , 268-77, (1992)

 Synonyms

Propandiyldichlorid
1,3-dichloropropan-2-one O-benzyloxime
MFCD00000999
1,3-dichloro-2-propanone O-benzyloxime
EINECS 205-531-3
1,3-Dichlor-propan
1,3-dichloro-propane
Propane, 1,3-dichloro-
1,3-Dichloropropane
Trimethylene dichloride
1,3-dichlorpropane
Trimethylene Chloride
3-chloropropyl chloride
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